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Integrative Physiology & Pharmacology Ph.D. Program at Wake Forest University


Wake Forest University Graduate School » Integrative Physiology & Pharmacology Ph.D. Program

Patricia E. Gallagher, Ph.D.

Patricia E. Gallagher, Ph.D.
Education & Training BS University of Memphis 1972 PhD University of Tennessee-Memphis 1983 Fellowship Temple University School of Medicine 1986

 

Gallagher PE, Maglic D, Krishnan B, Castellino SM, Tallant EA. Angiotensin-(1-7) inhibits the growth of human pediatric rhabdomyosarcoma in a mouse xenograft model [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando (FL). Philadelphia (PA): AACR. 2011; ():Abstr 5349. Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA. Angiotensin peptides and lung cancer. Curr Cancer Drug Targets. 2011; 11(4):394-404. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010; 4(1):17-25. Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) reduces angiotensin II-induced remodeling of the microcirculation [abstract]. Hypertension. 2010; 56(5):e141-e142. Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010; 23(6):687-693. Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010; 70(21):8319-8328. Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Oxidative stress and low expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in dorsal medulla of hypertensive (mRen2)27 transgenic rats [abstract]. Hypertension. 2010; 56(5):e156. Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010; 299(1):F35-F42. Soto-Pantoja DR, Petty WJ, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits triple negative tumor growth through the inhibition of angiogenesis and a reduction in placental growth factor PIGF [abstract]. Cancer Res. 2009; 69(2 Suppl):103S. Tallant EA, McCollum LT, Gallagher PE. Angiotensin-(1-7) reduces Ang II-induced cardiac hypertrophy with an associated increase in the dual-specificity phosphatase 1 (DUSP1) [abstract]. Hypertension. 2009; 54(4):e122. Cook KL, Soto PD, Gallagher P, Tallant EA. Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of AKT [abstract]. Cancer Res. 2009; 69(2 Suppl):240S. Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology. 2009; 150(8):3753-3758. Gallagher PE, Tallant EA. Angiotensin-(1-7) reduces MAP kinase activity by upregulation of the dual-specificity phosphatase DUSP1 [abstract]. Hypertension. 2009; 54(4):e35. Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Protein phosphatase 1b activity in the solitary tract nucleus is necessary for normal baroreflex function [abstract]. Hypertension. 2009; 54(4):e100. Lesser GJ, Carver KA, Newton SJ, Tallant EA, Gallagher PE. Angiotensin-(1-7), a small molecule inhibitor of glioblastoma growth [abstract]. J Clin Oncol. 2009; 27(15 Suppl):2024. Anton L, Merrill DC, Neves LAA, Diz DI, Corthorn J, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB, et al. The uterine placental bed renin-angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009; 150(9):4316-4325. Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension. 2009; 54(5):1001-1008. Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone. Clin Cancer Res. 2009; 15(23):7398-7404. Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I study of angiotensin-(1-7), an endogenous antiangiogenic hormone: clinical, pharmacokinetic, and biomarker findings [abstract]. Mol Cancer Ther. 2009; 8(12 Suppl 1):B208. Soto-Pantoja DR, Menon J, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Mol Cancer Ther. 2009; 8(6):1676-1683. Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Tallant EA, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008; 93(5):694-700. Lesser G, Carver K, Newton S, Tallant EA, Gallagher P. Angiotensin-(1-7) inhibits the growth of human glioblastoma xenografts in nude mice [abstract]. Neuro Oncol. 2008; 10(5):792. Menon J, Miller MS, Soto-Pantoja DR, Callahan MF, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces lung tumor incidence in a novel bitransgenic Ki-ras G12C mouse model of lung tumorigenesis through a reduction in cyclooxygenase-2 [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR. 2008; ():Abstr 4654. Tallant EA, Gallagher PE, Ferrario CM, inventors; Wake Forest University Health Sciences, assignee. Angiotensin (1-7) and angiotensin (1-7) agonists for inhibition of cancer cell growth. United States patent US 7,375,073. 2008 May 20. 2008; ():. McCollum LT, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates cardiac fibrosis and vascular hypertrophy in a model of angiotensin II-dependent hypertension [abstract]. Hypertension. 2008; 52(4):e120. Arnold AC, Shaltout HA, Gallagher PE, Ganten D, Ferrario CM, Diz DI. Leptin impairs baroreflex sensitivity at the solitary tract nucleus: evidence for upregulation of leptin actions in animals with low brain angiotensinogen [abstract]. Hypertension. 2008; 52(4):e50. Gallagher PE, Soto-Pantoja DR, Tallant EA. Angiotensin-(1-7) reduces endothelial cell growth and migration and increases VEGI to inhibit angiogenesis [abstract]. Hypertension. 2008; 52(4):e72. Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Robbins ME, Diz DI. Long-term systemic renin-angiotensin system blockade alters expression of renin-angiotensin system components in dorsomedial medulla of Fischer 344 rats [abstract]. Hypertension. 2008; 52(4):e61. Anton L, Merrill D, Diz D, Neves L, Gallagher P, Stovall K, Moorefield C, Gruver C, Ferrario C, Brosnihan KB. Does the activated RAS with suppression of all Ang receptors in the preeclamptic maternal uterus play an endocrine role on the placenta? [abstract]. Hypertens Pregnancy. 2008; 27(4):508. Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Bi-directional translational research with angiotensin-(1-7) uncovers placental growth factor as a therapeutic target [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research ; 2008 Apr 12-16; San Diego (CA). Philadelphia (PA): AACR. 2008; ():Abstr 4968. Anton L, Merrill DC, Neves LAA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preelampsia. Hypertension. 2008; 51(4):1066-1072. Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low-dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008; 2(2):106-115. Diz DI, Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Averill DB. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008; 51(6):542-548. Soto-Pantoja DR, Menon J, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits the growth of human triple negative breast tumors in an orthotopic model [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research ; 2008 Apr 12-16; San Diego (CA). Philadelphia (PA): AACR. 2008; ():Abstr 2416. Gallagher PE, Ferrario CM, Tallant EA. MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. Am J Physiol Cell Physiol. 2008; 295(5):C1169-1174. Garcia-Espinosa MA, Shaltout HA, Chappell MC, Gallagher PE, Ferrario CM, Ganten D, Reudelhuber TL, Diz DI. Angiotensin-(1-7) replacement gene transfer in the cisterna magna lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats [abstract]. Hypertension. 2008; 52(4):e36. Tallant EA, McCollum LT, Gallagher PE. Angiotensin-(1-7) increases DUSP-1 and reduces the endothelin-1-mediated increase in COX-2 and PGES-1 in cardiac fibroblasts [abstract]. Hypertension. 2008; 52(4):e47-e48. Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008; 2(2):106-115. Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts. Am J Physiol Heart Circ Physiol. 2008; 295(6):H2373-79. Yamaleyeva LM, Lindsey SH, Gallagher PE, Chappell MC. Distribution and regulation of the novel estrogen receptor GPR30 in the female mRen2.Lewis rat kidney [abstract]. Hypertension. 2008; 52(4):e93. Neves LAA, Stovall K, Joyner J, Valdes G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Am J Physiol Regul Integr Comp Physiol. 2008; 294(1):R151-R161. Brosnihan KB, Hodgin JB, Smithies O, Maeda N, Gallagher P. Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Exp Physiol. 2008; 93(5):658-664. Anton L, Merrill DC, Diz D, Neves LA, Gallagher PE, Stovall K, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Elevation of maternal uterine placental bed angiotensin II levels is associated with increased renin and ACE mRNA in preeclampsia [abstract]. Hypertension. 2008; 52(4):e49. Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I trial of angiotensin-(1-7): an endogenous anti-angiogenic hormone [abstract]. J Clin Oncol. 2008; 26(15 Suppl):634s. Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC. Ovariectomy is protective against renal injury in the high-salt fed older mRen2.Lewis rat. Am J Physiol Heart Circ Physiol. 2007; 293(4):H2064-2071. Gallagher PE, Soto-Pantoja DR, Tallant EA. Angiotensin-(1-7) inhibits angiogenesis by reducing endothelial cell growth [abstract]. Hypertension. 2007; 50(4):e91. Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats. Am J Physiol Regul Integr Comp Physiol. 2007; 292(2):R819-R826. Anton L, Merrill DC, Diz DI, Neves LA, Stovall K, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated by the AT1 receptor [abstract]. Hypertension. 2007; 50(4):e79. Brosnihan KB, Stovell K, Gallagher PE, Ferrario CM, Neves LA. Intrauterine Ang-(1-7) infusion attenuates PGE2 and PGF1 alpha but not TXB2 in decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2007; 50(4):e102. Varagic J, Brosnihan KB, Groban L, Gallagher PE, Ferrario CM. Decreased expression of cardiac ACE2 is associated with salt-induced cardiac remodeling and dysfunction [abstract]. Hypertension. 2007; 50(4):e150. Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Diz DI, Gallagher PE, Neves L, Tallant EA. Regulation of cardiovascular control mechanisms by angiotensin (1-7) and angiotensin-converting enzyme 2. In: Carey RM, ed. Hypertension and hormone mechanisms. Totowa (NJ): Humana Press; 2007: 43-59. Tallant EA, Gallagher PE. Angiotensin-(1-7) upregulates the mitogen-activated phosphatase DUSP1 in vascular smooth muscle cells [abstract]. Hypertension. 2007; 50(4):e77. Menon J, Soto-Pantoja DR, Callahan MF, Cline JM, Ferrario CM, Tallant EA, Gallagher PE. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Res. 2007; 67(6):2809-2815. Yamaleyeva LM, Gallagher PE, Groban L, Chappell MC. Increased intra-renal IGF-1 is associated with renal injury in older estrogen-depleted mRen2.Lewis rats [abstract]. FASEB J. 2007; 21(6 Pt II):A1421. Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol. 2007; 292(3):H1412-1419. Diz DI, Tommasi EN, Ferrario CM, Tallant EA, Gallagher PE. ACE2 inhibition in the nucleus of the solitary tract reduces baroreceptor reflex sensitivity [abstract]. Hypertension. 2006; 48(4):e87. Jessup JA, Gallagher PE, Chappell MC, Ferrario CM. Impaired counter-regulatory response of angiotensin converting enzyme 2 (ACE2) and angiotensin-(1-7) [Ang-(1-7)] in the heart of a new congenic model of hypertension derived from [mRen2]27 transgenic rats [abstract]. Hypertension. 2006; 48(4):e74. Tallant EA, Ferrario CM, Gallagher PE. Cardioprotective role for angiotensin-(1-7) and angiotensin converting enzyme 2 in the heart. Future Cardiol. 2006; 2(3):335-342. Menon J, Tallant EA, Gallagher PE. Experimental and molecular therapeutics 17: novel therapeutic targets [abstract]. In: Proceedings of the 97th Annual Meeting of the American Association for Cancer Research ; 2006 Apr 1-5; Washington, DC. Philadelphia (PA): AACR. 2006; ():Abstr 2160. Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Ferrario C, et al. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006; 291(6):F1308-1314. Gallagher PE, Tallant EA, Ferrario CM. Angiotensin converting enzyme 2: a potential target for cardiovascular therapy. In: Re RN, DiPette DJ, Schiffrin EL, Sowers JR, eds. Molecular mechanisms in hypertension. New York: Taylor & Francis; 2006: 51-59. Conner KR, Forbes ME, Gallagher PE, Robbins ME, Riddle DR. Assessing the effects of AT1 receptor blockade on WBI-induced brain damage [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):. Anton L, Merrill DC, Neves LA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased expression of AT1 receptor and angiotensinogen mRNA and Ang II in human placental chorionic villi of preeclamptic pregnant subjects [abstract]. Hypertension. 2006; 48(4):e95. Joyner J, Neves L, Gallagher P, Merrill D, Ferrario C, Brosnihan KB. Counter-regulation of ACE and ACE2 gene expression in the kidney of normal pregnant rats [abstract]. Hypertension. 2006; 48(4):e95. Tallant EA, Menon J, Soto-Pantoja DR, Gallagher PE. Angiotensin peptides and cancer. In: Kastin AJ, ed. Handbook of biologically active peptides. Boston: Academic Press; 2006: 459-465. Neves LAA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006; 27(11):2912-2918. Joyner J, Neves LAA, Gallagher PE, Chappell MC, Ferrario CM, Brosnihan KB. Kidney ACE2 mRNA and activity in virgin and normal pregnant Sprague Dawley rats [abstract]. J N C Acad Sci. 2006; 122(2):80. Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Am J Physiol Heart Circ Physiol. 2006; 291(5):H2166-2172. Brosnihan KB, Neves LA, Gallagher P, Hodgin JB, Smithies O, Maeda N. Differential regulation by ER alpha and ER beta for ACE and ACE2 [abstract]. Hypertension. 2006; 48(4):e49. Garcia-Espinosa MA, Vinsant S, Gallagher PE, Ferrario CM, Ganten D, Chappell MC, Diz DI. Regulation of brain neprilysin and ACE2 in transgenic rats during aging [abstract]. Am J Med Sci. 2006; 331(2):61. Neves LA, Stovall K, Gallagher PE, Valdes G, Ferrario CM, Merrill DC, Brosnihan KB. Ang-(1-7) concentration and ACE2 mRNA levels are downregulated during the process of implantation and decidualization in Sprague-Dawley rats [abstract]. Hypertens Pregnancy. 2006; 25(Suppl 1):20. Soto-Pantoja DR, Gallagher PE, Tallant EA. Inhibition of angiogenesis by angiotensin-(1-7) [abstract]. In: Proceedings of the 97th Annual Meeting of the American Association for Cancer Research ; 2006 Apr 1-5; Washington, DC. Philadelphia (PA): AACR. 2006; ():Abstr 950. Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Reudlehuber TL, Diz DI. Intracisternal injection of angiotensin-(1-7)-producing fusion protein plasmid lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. Hypertension. 2006; 48(4):e87. Gallagher PE, Ferrario CM, Tallant EA. Molecular mechanisms for the regulation of angiotensin converting enzyme 2 by angiotensin peptides in vascular smooth muscle cells [abstract]. Hypertension. 2006; 48(4):e72. McCollum LT, Gallagher PE, Ferrario CM, Tallant EA. Angiotensin-(1-7) reduces COX-2 in cardiac fibroblasts [abstract]. Hypertension. 2006; 48(4):e79.