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Integrative Physiology & Pharmacology Ph.D. Program at Wake Forest University


Wake Forest University Graduate School » Integrative Physiology & Pharmacology Ph.D. Program

James Daunais

James Daunais
Research focuses on the neurobiological consequences of exposure to abused substances, including alcohol and stimulants. Brain imaging methods such as quantitative receptor and G-protein autoradiography and in situ hybridization histochemistry techniques, are combined with genomic analysis to determine mechanisms of action of abused drugs at various transporter and receptor systems. Noninvasive multimodal magnetic resonance imaging (MRI) methods are used to track developmental and drug-induced changes in brain structure and function over time. We utilize various MRI pulse sequences to analyze changes in structural anatomy (structural imaging), brain metabolites (magnetic resonance spectroscopy (MRS)), cerebral blood flow using arterial spin labeling (ASL), white matter integrity (diffusion tensor imaging) and neural function (functional MRI)  to identify the biological and functional correlates that result from repeated drug use. We also apply magnetoencephalography (MEG) in the nonhuman primate brain to directly measure neural activity with millisecond temporal resolution.

 

  • Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neeley D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SRn Shively CA. Long Term Sertraline Effects on Neural Structures in Depressed and Nondepressed Female Nonhuman Primates. Neuropharmacology. 2015; [Epub ahead of print].
  • Pleil KE, Helms C, Sobus J, Daunais JB, Grant KA, Kash TL. Effects of Chronic Alcohol Consumption on Neuronal Function in the Primate Extended Amygdala. Addiction Biology. 2015; [Epub ahead of print].
  • Davenport AT, Grant KA, Szeliga KT, Friedman DP, Daunais JB. Standardized method for the harvest of nonhuman primate tissue optimized for multiple modes of analyses. Cell Tissue Banking., 2014; 15 (99): 99-110. PMID: 23709130, PMCID:  PMC3809161
  • Maldjian JA, Daunais JB, Friedman DP, Whitlow CT. Vervet MRI atlas and label map for fully automated morphometric analyses. J Neuroinform. 2014; [Epub ahead of print] PMID: 24850577
  • Daunais JB, Davenport AT, Helms CM, Gonzales SW, Hemby SE, Friedman DP, Farro JP, Baker EJ, Grant KA. Monkey Alcohol Tissue Research Resource: Banking tissues for alcohol research. Alcohol Clin Exp Res., 2014; [Epub ahead of print]. PMID: 24942558
  • Murnane KS, Gopinath KS, Maltbie E, Daunais JB, Telesford QK, Howell LL. Functional connectivity in frontal-striatal brain networks and cocaine self-administration in female rhesus monkeys. Psychopharmacology. 2014 [Epub ahead of print]. PMID: 25138647
  • Daunais JB, Kraft RA, Davenport AT, Burnett EJ, Maxey VM, Szeliga KT, Rau AR, Flory GS, Hemby SE, Friedman DP, et al. MRI-guided dissection of the nonhuman primate brain: a case study. Methods. 2010; 50(3):199-204.
  • Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P. Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010; 34(7):1-11.
  • Acosta G, Hasenkamp W, Daunais JB, Friedman DP, Grant KA, Hemby SE. Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys. Brain Res. 2010; 1318():144-154.
  • Willard SL, Daunais JB, Shively CA. Magnetic resonance imaging of whole, anterior and posterior hippocampal volumes in behaviorally depressed cynomolgus macaques [abstract]. Biol Psychiatry. 2010; 67(9 Suppl):52S.
  • Wilson TW, Godwin DW, Czoty PW, Nader MA, Kraft RA, Buchheimer NC, Daunais JB. A MEG investigation of somatosensory processing in the rhesus monkey. Neuroimage. 2009; 46(4):998-1003.
  • Friedman DP, Dolson EP, Maxey VM, Burnett EG [sic] [Burnett EJ], Daunais JB, Davenport AT. Effect of chronic ethanol on 5HT1(A) densities and serotonin transporter levels in the dorsal raphe of mother-reared vs nursery-reared macaques [abstract]. Alcohol Clin Exp Res. 2009; 33(6 Special Issue):23A.
  • Bruce NA, Wolstenholme JT, Daunais JB, Rau A, Keily C, Grant KA, Miles MF. Gene expression pattern changes in monkey prefrontal cortex following chronic ethanol self-administration [abstract]. Alcohol Clin Exp Res. 2009; 33(6 Special Issue):203A.
  • Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA. Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. J Card Fail. 2009; 15(Suppl 6):S42.
  • Burnett EJ, Friedman DP, Daunais JB. Changes in amygdala volume associated with early life stress in rhesus macaques (Macaca mulatta) [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.
  • Davenport AT, Maxey VM, Daunais JB, Friedman DP. Effect of chronic ethanol on 5HT1A densities and serotonin transporter levels in the prefrontal cortex of mother-reared vs nursery-reared macaques [abstract]. Alcohol Clin Exp Res. 2008; 32(Suppl 1):34A.
  • Williams JK, Baptista PM, Daunais JB, Szeliga KT, Friedman DP, Soker S. The effects of ethanol consumption on vasculogenesis potential in nonhuman primates. Alcohol Clin Exp Res. 2008; 32(1):155-161.
  • Hemby SE, Hanlon CA, Horman B, Sikoski P, Daunais J, Kraft R, Porrino LJ. MRI assessment of chronic antipsychotic administration in rhesus monkeys [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.
  • Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR. A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Alcohol Clin Exp Res. 2008; 32(6 Suppl 1):35A.
  • Anderson NJ, Daunais JB, Friedman DP, Grant KA, McCool BA. Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors. Alcohol Clin Exp Res. 2007; 31(6):1061-1070.
  • Daunais JB, Liu W, Wyatt CL, Szeliga KT, Buchheimer NC, Gage HD, Kraft RA, Friedman DP. Ethanol-induced volume changes in Macaque brain [abstract]. Alcohol Clin Exp Res. 2007; 31(6 Suppl):147A.
  • Ivester P, Roberts LJ II, Young T, Vivian J, Lees C, Young J, Daunais J, Friedman D, Grant KA, Cunningham C, et al. Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Alcohol Clin Exp Res. 2007; 31(1):144-155.
  • Davenport AT, Szeliga KT, Moser VM, Daunais JB, Friedman DP. Effect of chronic ethanol on 5HT1A and serotonin transporter densities in the hippocampus and raphe of mother-reared vs peer-reared macaques [abstract]. Alcohol Clin Exp Res. 2007; 31(Suppl 2):208A.
  • Hampson R, Porrino LJ, Daunais JB, Miller M, Hanlon CA, Morgan AR, Gill KE, Long J, Ramirez S, Todd M, Deadwyler SA. Sleep deprivation disrupts brain glucose utilization and performance on high vs. low cognitive load trials during a delayed-match-to-sample (DMS) task in nonhuman primates [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):.
  • Carden WB, Alexander GM, Friedman DP, Daunais JB, Grant KA, Mu J, Godwin DW. Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates. Brain Res. 2006; 1089():92-100.
  • Alexander GM, Carden WB, Mu J, Kurukulasuriya NC, McCool BA, Nordskog BK, Friedman DP, Daunais JB, Grant KA, Godwin DW. The native T-type calcium current in relay neurons of the primate thalamus. Neuroscience. 2006; 141(1):453-461.
  • Deadwyler SA, Porrino LJ, Daunais JB, Miller M, Hanlon CA, Morgan AR, Gill KE, Long J, Ramirez S, Todd M, Hampson RE. Evidence for the differential effects of modafinil and the ampakine CX717 on task-related brain glucose metabolism in sleep-deprived monkeys [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer).