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Integrative Physiology & Pharmacology Ph.D. Program at Wake Forest University


Wake Forest University Graduate School » Integrative Physiology & Pharmacology Ph.D. Program

Hossam A. Shaltout, Ph.D.

Hossam A. Shaltout, Ph.D.
My research interest focuses on investigation of brain role in blood pressure regulation. Emphasis is on the interaction between the renin angitotensin system components and the autonomic nervous system in different pathological conditions such as hypertension, metabolic syndrome, premature delivery, PTSD and aging. Approaches include whole animal physiological studies to test the effect of interruption of the renin angiotensin system either peripherally or centrally on the development of hypertension and metabolic disorder in animal model of antenatal exposure to betamethasone. I am also interested in the assessment of the RAS peptides, enzymes activity and receptors levels in multiple tissues of different animal models and studies to assess cardiovascular actions and signaling mechanisms of peptide transmitters at specific brain sites. I am also interested in neural and hormonal systems interactions in PTSD subjects and the changes in the autonomic nervous system and cardiovascular system after noninvasive treatment of brain wave optimization.  Currently I am involved in studies to compare the effect of western diet or Mediterranean diet on cardiovascular measures and the modulatory effect of social ranking on this response. Ongoing collaborative projects include investigations of the renin-angiotensin system and neural control of the circulation and indices of autonomic function in elderly hypertensives fed a high nitrate diet, and pediatric subjects with orthostatic intolerance.

 

  1. Shaltout HA, Abdel-Rahman AA. Cyclosporine induces progressive attenuation of baroreceptor heart rate response and cumulative pressor response in conscious unrestrained rats. J Pharmacol Exp Ther. 2003 Jun;305(3):966-73.
  2. Shaltout HA, Abdel-Rahman AA. Mechanism of fatty acids induced suppression of cardiovascular reflexes in rats, J Pharmacol Exp Ther. 2005 Sep;314(3):1328-37.
  3. Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC and Chappell MC. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007 Jan;292(1):F82-91.
  4. Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension, 2009 Feb;53(2):404-8. PMCID:PMC2674380
  5. Westwood, B.M, Shaltout, HA, Chappell, MC. Modeling of angiotensin peptide metabolism in renal proximal tubules. (2009) Proceedings of the ASME Summer Bioengineering Conference, SBC2008, pp. 181-182.
  6. Gwathmey TM, Shaltout HA, Pendegrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear Angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1484-93. PMCID:PMC2692453
  7. Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension, 2009 Nov; 54(5):1001-8. PMCID:PMC2789663
  8. Garcia-Espinosa MA, Shaltout HA, Olson J, Westwood BM, Robbins ME, Link K, Diz DI. Proton magnetic resonance spectroscopy detection of neurotransmitters in dorsomedial medulla correlate with spontaneous baroreceptor reflex function. Hypertension, 2010 Feb;55(2):487-93. PMCID:PMC2826127
  9. Shaltout HA, Rose, JC, Figueroa JP, Chappell MC, Diz DI,  Averill DB. Acute AT1 receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone. Am J PhysiolHeart Circ Physiol. 2010 Aug; 299(2):H541-7. PMCID:PMC2930394
  10. Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. Am J PhysiolHeart Circ Physiol. 2010 Sep; 299(3):H763-71. PMCID:PMC2944473
  11. Gwathmey TM, Shaltout HA, Rose JC, Diz DI, and Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011 Mar;57(3):620-6. PMCID:PMC3041840
  12. Diz DI, Arnold AC, Nautiyal M, Isa K, Shaltout HA and Tallant EA. Angiotensin peptides and central autonomic regulation. Curr Opin Pharmacol. 2011 Apr;11(2):131-7. PMID: 21367658. PMCID:PMC3120135
  13. Shaltout HA, Chappell MC, Rose JC and Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E979-85. PMID: 21386063. PMCID:PMC3118588
  14. Arnold AC, Shaltout HA, Gilliam-Davis S, Kock N, and Diz DI. Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2206-13. PMID: 21460193. PMCID:PMC3119102
  15. Logan EM, Aileru AA, Shaltout HA, Averill DB, Diz DI. The functional role of PI3K in maintenance of blood pressure and baroreflex suppression in (mRen2)27 and mRen2.Lewis rat. J Cardiovasc Pharmacol. 2011 Oct;58(4):367-73. PMID: 21697727. PMCID:PMC3188661
  16. Fortunato JE, Shaltout HA, Larkin MM, Rowe PC, Diz DI, Koch KL. Fludrocortisone improves nausea in children with orthostatic intolerance. Clinical Autonomic Research, Clin Auton Res. 2011 Dec;21(6):419-23. PMID: 21796356
  17. Kemper KJ, Shaltout HA. Non-verbal communication of compassion: measuring psychophysiologic effects. BMC Complement Altern Med. 2011 Dec 20;11:132. PMID: 22185349. PMCID:PMC3260157
  18. Shaltout HA, Rose JC, Chappell MC and Diz DI. Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal Betamethasone exposure-induced elevation in blood pressure. Hypertension. 2012 Feb;59(2):453-8. PMID: 22215705
  19. Shaltout HA, Tooze JA, Rosenberger E, Kemper KJ. Time, Touch, and Compassion:  Effects on Autonomic Nervous System and Well-being. Explore (NY). 2012 May-Jun;8(3):177-84 : PMID: 22560756
  20. Garcia-Espinosa MA, Shaltout HA, Gallager PE, Chappell MC and Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012 Aug;60(2):150-7. PMID: 22526299. PMCID:PMC3419797
  1. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats. Hypertension. 2012 Nov;60(5):1257-65. PMID: 23045456. PMCID:PMC3491885
  1. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI.  Response to Angiotensin-(1-7) and Bradykinin in Baroreceptor Reflex Sensitivity in Hypertension.  Hypertension. 2013 Feb;61(2):e20. Erratum in: Hypertension. 2013 May;61(5). Shaltout, Hossam A [added]de Lima, Daniel C [added]; do Nascimento, Kenia [added].
  2. Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI.  Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep.  Peptides, 2013 Jun; 44C:25-31. PMCID:PMC3690463
  3. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am J Physiology: Regul Integr Comp Physiol, 2013 Oct; 305(7):R679-R688. PMCID:PMC3798802
  4. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides. 2013 Dec 16;52C:74-81. doi: 10.1016/j.peptides.2013.12.006. PMID:24355101
  1. Tegeler CH, Lee SW, Shaltout HA. Significance of right anterior insula activity for mental health intervention. Letter to editor, JAMA Psychiatry. 2014;71(3):336. PMID: 24599239
  2. Fortunato JE, Wagoner AL, Harbinson RL, D’Agostino RB, Shaltout HA and Diz DI. Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance. JPGN, 2014; 59(1): 39-43. PMID: 25222805
  3. Chappel MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the ACE2-Angiotensin-(1-7)-Mas receptor axis: Intracellular actions, fetal programming and sex differences. Front Endocrinol 2014;4:1-13. PMID: 24409169
  4. Tarbell S, Shaltout HA, Wagoner AL, Diz DI, Fortunato JE. Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea. Exp Brain Res. 2014 Aug;232(8):2645-50. PMID: 24829068.
  1. Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC and Diz DI. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 Rats. Physiol Rep. 2014 Aug 28;2(8). pii: e12108. PMID: 25168868
  1. Lee SW, Gerdes L, Tegeler CC, Shaltout HA and Tegeler CH. A bihemispheric autonomic model for traumatic stress effects on health and behavior. Front Psychol. 2014 Aug 1;5: 843. PMID: 25136325
  1. El-Bassossy H and Shaltout HA, Allopurinol alleviates hypertension and proteinuria in high fructose, high salt and high fat induced model of metabolic syndrome. Translational Research. 2014 Nov 29. pii: S1931-5244(14)00424-1.PMID: 2552872
  2. Schaich CL, Shaltout HA, Grabenaur M, Thomas BF, Gallagher P, Howlett AC and Diz DI. Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. Journal of Cardiovascular Pharmacology, 2015 Jan 29. [Epub ahead of print] PMID: 25636077
  3. Tegeler CH, Shaltout HA, Tegeler CC, Gerdes L and Lee SW. Rightward dominance in temporal high frequency electrical asymmetry corresponds to higher resting heart rate and lower baroreflex sensitivity in a heterogeneous population, Brain and Behavior, 2015 Jun;5(6): Epub 2015 May 1.PMID: 26085968
  1. Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI, Marsh AP and Brinkley TE. Effects of resistance training with and without caloric restriction on arterial stiffness in older adults. American Journal of Hypertension, 2015 Aug 20. [Epub ahead of print]. PMID: 26297029
  2. Fortunato JE, Tegeler CL, Gerdes L, Lee SW, Pajewski NM, Franco ME, Cook JF, Shaltout HA and Tegeler CH. Use of an allostatic neurotechnology by adolescents with Postural Orthostatic Tachycardia Syndrome (POTS) is associated with improvements in heart rate variability and changes in temporal lobe electrical activity, Experimental Brain Research, 2016 Mar;234(3):791-8. PMID: 26645307
  3. Wagoner AL, Shaltout HA, Fortunato JE and Diz DI. Distinct neurohumoral biomarker profiles in children with hemodynamically-defined orthostatic intolerance may predict treatment options. AJP-Heart and Circulatory Physiology, 2016 Feb 1;310(3):H416-25. PMID: 26608337
  4. Yamaleyeva LM, Shaltout HA and Varagic J. Apelin-13 in blood pressure regulation and cardiovascular disease. Curr Opin Neprol Hypertens, 2016 Jun 2. [Epub ahead of print]. Review. PMID: 27258138
  5. Schaich CL, Grabenaur M, Thomas BF, Shaltout HA,Gallagher P Howlett AC and Diz DI. Medullary endocannabinoids contribute to the differential resting baroreflex sensitivity in rats with altered brain renin-angiotensin system expression. Front Physiol Integr Physiol. In press.
  6. Nixon PA, Shaltout HA, Snively BM, Russell GB, O'Shea TM and Washburn KL. Antenatal steroid exposure and heart rate variability in adolescents born with very low birth weight. Journal of pediatrics. In revision
  7. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O’Shea TM and Washburn LK. Antenatal Corticosteroids and the Renin-Angiotensin-Aldosterone System in Preterm Adolescents. Pediatrics. In revision.
  8. Washburn LK, , Nixon PA, Snively BM, Russell GB, Shaltout HA, South AM and O’Shea TM. Antenatal Corticosteroids and Cardio-metabolic Outcomes in Adolescents Born with Very Low Birth Weight. The journal of Peiaterics. In revision
  9. Tegeler CH, Cook JF, Tegeler CL, Hirsch JR, Shaltout HA, Simpson SL, Fidali BC, Gerdes L and Lee SW. Use of an allostatic neurotechnology is associated with symptom reduction, decreased temporal lobe high frequency asymmetry, and increased heart rate variability in individuals with self-reported PTSD. European Journal of Psychotraumatology, In revision
  10. Wagoner AL, Shaltout HA, Diz DI and Fortunato JE. Orthostatically-induced Nausea and Altered Neurohumoral Responses in Children with Chronic Nausea. Gastroentrology. In revision.
  11. Shaltout HA, Wagoner AL, Fortunato JE, Diz DI. Impaired hemodynamic response to head up tilt in adolescent with orthostatic intolerance. In preparation
  12. Shaltout HA, Marsh AP, Laurienti P, Basu S, Klebous CK, Kus N, Morgan A, DosSantos PC, Norris JL, Miller GD, Rejeski J, Hawfield AT, Diz DI and Kim-Shapiro DB. Effect of adding beet root juice to exercise on physical performance and cardiovascular measures in old hypertensive subjects. In preparation
  1. Tegeler CH, Shaltout HA, Pajewski NM, Tegeler CC, Lee SW and Gerdes L. Temporal lobe electrical asymmetry as a paradigm for assessing the RDoC domain of arousal. In preperation.
  1. De Lima DC, Shaltout HA, Coimbra C, and Diz DI. The Impairment of Hyperglycemia and Pressure Adjustments to Hemorrhage in TGR(ASrAogen) Rats Fed with Hypercaloric Diet. In preperation.
  2. De Lima DC, Do Nascimento K, Shaltout HA, Brosnihan KB, Chappell MC, Coimbra CC and Diz DI. Activation of HPA axis following a metabolic challenge in rats with low glial angiotensin. Am J Physiol Regul Integr Comp Physiol, in preperation.
  3. Tegeler CH, Tegeler CL, Cook JF, Lee SW, Gerdes L, Miles CM and Shaltout HA. Use of a closed-loop neurotechnology by athletes with persisting post-concussion symptoms is associated with symptom reduction, autonomic changes, and return to play. In peperation
  4. Hinton AO, Yan X, Henderson A, Xu P, Cao X, Saito K, McAfee B, Yan X , Zou F, Yang Y, Ding H, Garza A, Wang C, Yan C, Yu L, Khan SA, Zhu L, Reynolds CL, Logan EM, Aileru A, Shaltout HA, Tong Q,  Chan L and Xu Y. Estrogen responsive neurons in the medial amygdala prevent stress-induced hypertension. In preparation