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Integrative Physiology & Pharmacology Ph.D. Program at Wake Forest University


Wake Forest University Graduate School » Integrative Physiology & Pharmacology Ph.D. Program

Graca Almeida-Porada, M.D., Ph.D.

Graca Almeida-Porada, M.D., Ph.D.

Professor, Institute for Regenerative Medicine

Additional Languages

Portuguese

Education & Training

  • M.D., University of Porto Faculty of Medicine-Portugal , 1985
  • Ph.D., University of Porto Faculty of Medicine-Portugal , 1994

Memberships

  • Am Assn Of Blood Banks
  • Am Federation Of Clinical Rese
  • Am Soc Of Hematology

 

Sanada C, Kuo CJ, Colletti EJ, Soland M, Mokhtari S, Knovich MA, Owen J, Zanjani ED, Porada CD, Almeida-Porada G. Mesenchymal stem cells contribute to endogenous FVIII:c production. J Cell Physiol. 2013;228(5):1010-1016.

 

Soland MA, Bego M, Colletti E, Zanjani ED, St Jeor S, Porada CD, Almeida-Porada G. Mesenchymal stem cells engineered to inhibit complement-mediated damage. PLoS One. 2013;8(3):e60461.

 

 

 

Colletti E, El Shabrawy D, Soland M, Yamagami T, Mokhtari S, Osborne C, Schlauch K, Zanjani ED, Porada CD, Almeida-Porada G. EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool. FASEB J. 2013;27(6):2111-2121.

 

Kuo C-J, Mokhtari S, Soland M, Soker S, Yoo J, Owen J, Knovich MA, Atala A, Almeida-Porada G, Porada C. Amniotic fluid stem cells for the treatment of hemophilia A [abstract]. Mol Ther. 2013;21(Suppl 1):S96-S97.

 

Almeida-Porada G, Soland M, Boura J, Porada CD. Regenerative medicine: prospects for the treatment of inflammatory bowel disease. Regen Med. 2013;8(5):631-644.

 

 

Tellez J, Van Vliet K, Tseng Y-s, Finn J, Tschernia N, Almeida-Porada G, Arruda V, Agbandje-McKenna M, Porada C. Characterization of naturally-occurring humoral immunity to AAV in sheep [abstract]. Mol Ther. 2012;20(Suppl 1):S101.

 

Soland MA, Bego MG, Colletti E, Porada CD, Zanjani ED, St Jeor S, Almeida-Porada G. Modulation of human mesenchymal stem cell immunogenicity through forced expression of human cytomegalovirus US proteins. PLoS ONE. 2012;7(5):e36163.

 

Wood JA, Colletti E, Mead LE, Ingram D, Porada CD, Zanjani ED, Yoder MC, Almeida-Porada G. Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model. Hepatology. 2012;56(3):1086-1096.

 

Porada CD, Almeida-Porada G. Treatment of hemophilia A in utero and postnatally using sheep as a model for cell and gene delivery. J Genet Syndr Gene Ther. 2012;Suppl 1():011.

 

Zakas PM, Gangadharan B, Almeida-Porada G, Porada CD, Spencer HT, Doering CB. Development and characterization of recombinant ovine coagulation factor VIII. PLoS One. 2012;7(11):e49481.

 

Mokhtari S, Colletti E, Porada CD, Almeida-Porada G. Origin and characterization of CD166+ cells during human marrow ontogeny [abstract]. Blood. 2012;120(21):1252.

 

Soland M, Keyes L, Porada CD, St Jeor S, Almeida-Porada G. Niche perivascular stromal cells as a potential reservoir and a source of HCMV reactivation [abstract]. Blood. 2012;120(21):3464.

 

Andrade PZ, da Silva CL, dos Santos F, Almeida-Porada G, Cabral JMS. Initial CD34+ cell-enrichment of cord blood determines hematopoietic stem/progenitor cell yield upon ex vivo expansion. J Cell Biochem. 2011;112(7):1822-1831.

 

Porada CD, Sanada C, Kuo C-J, Colletti E, Moot R, Doering C, Spencer HT, Almeida-Porada G. Postnatal transplantation of FVIII-expressing MSC phenotypically corrects hemophilia A [abstract]. Mol Ther. 2011;19(7):1364.

 

Cary LH, Almeida-Porada G, Noutai D, Ngudiankama BF, Whitnall MH. Endothelial cells modulate hematopoietic cell recovery after mixed field irradiation [abstract]. Exp Hematol. 2011;39(8 Suppl 1):S66.

 

Porada CD, Sanada C, Kuo C-J, Colletti E, Mandeville W, Hasenau J, Zanjani ED, Moot R, Doering C, Spencer HT, Almeida-Porada G. Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC. Exp Hematol. 2011;39(12):1124-1135.

 

Dr. Almeida-Porada was born and raised in Portugal. She received her medical degree in 1986 from the Instituto de Ciências Biomédicas Abel Salazar (ICBAS) of University of Porto, Portugal. She completed her residency and fellowship in Hematology/Transfusion Medicine at University Hospital of Santo Antonio, and obtained her Ph.D. in Pathology from ICBAS in 1995.  She was a fellow at the University of Connecticut Health Center and at the University of Nevada, Reno School of Medicine. She became faculty at the University of Nevada, Reno in 1999. In 2001 she joined the Department of Animal Biotechnology at the same Institution, where she was a Professor and the Director of Graduate Studies. In 2006 she was inducted into Phi Beta Delta. She serves on the Editorial Boards of several scientific journals, and was an Associate Editor for Experimental Hematology. Dr. Almeida-Porada has authored more than 90 scientific publications and reviews, and has written chapters in several books.  She joined the faculty at WFIRM in 2011.

SYNOPSIS OF AREA OF INTEREST: Dr. Almeida-Porada’s researchfocuses on the study of the biological properties and regenerative capabilities of adult stem cells, with the goal of understanding disease processes and developing novel approaches to cell therapy and tissue repair. 

DETAILED AREA OF INTEREST: The study of stem cell biology provides a unique tool to gain a better understanding into the myriad of interwoven pathways involved in development, specification of cell fate, and tissue regeneration/repair.  Furthermore, it can unravel the complex cell-cell interactions that control migration/homing and differentiation of cells during injury/repair and following transplantation. The Almeida-Porada laboratory is interested in investigating these basic biologic processes, using bone marrow and cord blood-derived stem cells as model systems, and translating the knowledge obtained to develop cell-based therapies for different organs/diseases. Specifically, we are delineating the pathways and the factors that govern stem cell expansion and differentiation into specific fates, by studying stem cells in their own microenvironment, at the niche level, and upon transplantation in injury and non-injury models. We are also devising techniques to improve the engraftment of transplanted cells through manipulation of the recipient’s niches and modulation of the transplanted cells’ immunogenicity. Collectively, we envision that the key information generated from each of the ongoing projects will provide the necessary tools for developing: 1) ways to obtain and expand non-immunogenic tissue-specific progenitor cells to be used in tissue engineering; and 2) new and safer approaches to cell therapy, including manipulation of stem cell niches to stimulate proliferation of endogenous stem cells, and/or facilitate engraftment and accelerate recovery after stem cell transplantation.