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Integrative Physiology & Pharmacology Ph.D. Program at Wake Forest University


Wake Forest University Graduate School » Integrative Physiology & Pharmacology Ph.D. Program

Colin Edward Bishop, Ph.D.

Colin Edward Bishop, Ph.D.

Dr. Colin Bishop was born in Portsmouth, England. He received his Ph.D in Immunogenetics in 1979 from the Department of Immunology, London Hospital Medical College, University of London. After a postdoctoral fellowship at the Netherlands Cancer Institute, Amsterdam, he moved to the Institute Pasteur, Paris in 1981 where he worked on the genetics of sex-determination. In 1990 he moved to the University of Tennessee, Memphis where he was Professor in the Departments of Obstetrics & Gynecology and Microbiology & Immunology, and Director of basic research for the OB/GYN laboratories. In 1993 he returned to France to direct the INSERM (NIH equivalent) research unit 406 “Medical Genetics and Development” at the La Timone Hospital, Marseille. He was also a founding member of the “Developmental Biology Institute of Marseille-Luminy” (IBDM). After 3 years he returned to the USA to take up the position of Professor at Baylor College of Medicine, Houston in the Department of Obstetrics & Gynecology, with a joint appointment as Professor in the Department of Molecular & Human Genetics. He also directed the basic research program for OB/GYN Laboratories. He joined WFIRM in September 2006 and directs the genetics and developmental biology component of the Institute.

 

Campeau L, Hicks A, Burmeister D, Bishop C, Andersson KE. Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2)- consequences for mouse bladder development and function [abstract]. Neurourol Urodyn. 2013;32(2):130.

 

Beck TF, Shchelochkov OA, Yu Z, Kim BJ, Hernandez-Garcia A, Zaveri HP, Bishop C, Overbeek PA, Stockton DW, Justice MJ, Scott DA. Novel Frem1-related mouse phenotypes and evidence of genetic interactions with Gata4 and Slit3. PLoS One. 2013;8(3):e58830.

 

Jiao Y, Bishop CE, Lu B. Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth. Mol Biol Cell. 2012;23(8):1404-1413.

 

George SK, Jiao Y, Bishop CE, Lu B. Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice. Free Radic Biol Med. 2012;52(11-12):2223-2233.

 

Hicks AN, Lorenzetti D, Gilley J, Lu B, Andersson KE, Miligan C, Overbeek PA, Oppenheim R, Bishop CE. Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo. PLoS One. 2012;7(10):e47869.

 

Jiao Y, George SK, Zhao Q, Hulver MW, Hutson SM, Bishop CE, Lu B. Mex3c mutation reduces adiposity and increases energy expenditure. Mol Cell Biol. 2012;32(21):4350-4362.

 

 

Moorefield EC, McKee EE, Solchaga L, Orlando G, Yoo JJ, Walker S, Furth ME, Bishop CE. Cloned, CD117 selected human amniotic fluid stem cells are capable of modulating the immune response. PLoS ONE. 2011;6(10):e26535.

 

Hicks A, Lorenzetti D, Lu B, Andersson K-E, Overbeek P, Oppenheim R, Bishop C.Nervous system defects in the novel bloated bladder mouse mutant (BLAD) [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):33.15.

 

Soler R, Fullhase C [Fuellhase C], Lu B, Bishop CE, Andersson K-E. Bladder dysfunction in a new mutant mouse model with increased superoxide--lack of nitric oxide?. J Urol. 2010;183(2):780-785.

 

Valli A, Rosner M, Fuchs C, Siegel N, Bishop CE, Dolznig H, Madel U, Feichtinger W, Atala A, Hengstschlager M. Embryoid body formation of human amniotic fluid stem cells depends on mTOR. Oncogene. 2010;29(7):966-977.

 

Pan C, Lu B, Chen H, Bishop CE. Reprogramming human fibroblasts using HIV-1 TAT recombinant proteins OCT4, SOX2, KLF4 and c-MYC. Mol Biol Rep. 2010;37(4):2117-2124.

 

Pan CY, Hicks A, Guan X, Chen H, Bishop CE. SNL fibroblast feeder layers support derivation and maintenance of human induced pluripotent stem cells. J Genet Genomics. 2010;37(4):241-248.

 

Pan C, Lan X, Chen H, Bishop CE. An economical single-sided antibody incubation method for Western blotting. J Virol Methods. 2010;169(2):409-411.

 

Bishop CE. Tissue engineering in andrology [abstract]. J Androl. 2009;30(Suppl):12.

 

Anderson PD, Lam M-Y, Poirier C, Bishop CE, Nadeau JH. The role of the mouse Y chromosome on susceptibility to testicular germ cell tumors. Cancer Res. 2009;69(8):3614-3618.

 

Chung Y, Bishop CE, Treff NR, Walker SJ, Sandler VM, Becker S, Klimanskaya I, Wun W-S, Atala A, Lanza R, et al. Reprogramming of human somatic cells using human and animal oocytes. Cloning Stem Cells. 2009;11(2):213-223.

 

Fullhase C [Fuellhase C], Soler R, Lu B, Bishop CE, Andersson KE. Increased levels of superoxide ions affects bladder function in a new mutant mouse model [abstract]. Eur Urol Suppl. 2009;8(4):176.

 

Soler R, Fuellhase C, Lu B, Bishop C, Andersson K. Bladder dysfunction in a new animal model of increased levels of superoxide ions [abstract]. Neurourol Urodyn. 2009;28(7):809-810.

 

Lu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, Matzuk MM, Andersson K-E, Overbeek PA, Bishop CE. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Biol Reprod. 2008;78(4):601-610.

 

De Filippo RE, Bishop CE, Filho LF, Yoo JJ, Atala A. Tissue engineering a complete vaginal replacement from a small biopsy of autologous tissue. Transplantation. 2008;86(2):208-214.

 

Poirier C, Moran JL, Kovanci E, Petit DC, Beier DR, Bishop CE. Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods/+ mice [letter]. Genesis. 2007;45(7):452-455.

 

Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeck PA, Bishop CE.Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Mamm Genome. 2007;18(5):338-346.

 

Feng S, Bogatcheva NV, Truong A, Korchin B, Bishop CE, Klonisch T, Agoulnik IU, Agoulnik AI. Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs. Biol Reprod. 2007;77(4):671-680.

 

SYNOPSIS OF AREA OF INTEREST: Dr. Bishop’s research interests are focused on reproductive genetics. These include primary sex-determination, germ cell development, stem cell biology and human reproductive failure.

DETAILED AREA OF INTEREST: The overall focus concerns the genetics of primary sex determination, germ cell development and fertility. Two main themes are being developed. The first is concerned with the genetic basis of primary sex determination and germ cell development. In order to address this problem we are generating a national resource of new mouse strains, carrying mutations in genes affecting fertility and sex determination. This project which uses novel transposon technology can be seen at <http://mousegenome.bcm.tmc.edu/bartmice/>. We have now begun to analyze several selected new infertility mutants generated in this program. These involve XX female-to-male sex-reversal; male and/or female infertility, due to defects at specific stages of germ cell development; sperm-egg fusion and pre-implantation failure. All of these models were chosen as they closely mimic aspects of sex-reversal and human infertility conditions such as those seen in XX(Y-) sex reversal/gonadal dysgenesis, Sertoli Cell only syndrome, Premature Ovarian Failure, and failure of egg penetration. As such, they represent attractive animal models for investigating the regulation of these developmental processes and provide an important component in the generation of knowledge-based therapies. We have recently expanded this technology to modify the rat genome which is particularly relevant due to the fact that despite worldwide efforts, rat embryonic stem cells have not yet been produced.
The second main theme is the identification of genetic factors influencing stem cell renewal and differentiation during gametogenesis. We are particularly interested in deriving functional germ cells from adult-derived stem cells. Our long term goal is to be able to repopulate the testes or ovaries of infertile patients with germ cells derived from autologous tissue.

Reproductive genetics touches the very core of our existence – the ability of human beings to procreate. Developments in this field have led to legal and ethical issues which society has yet to resolve. Assisted reproductive technologies have forced society to re-examinE the current concept of the family, the right of every human to create life, and the rights of potential children and parents. It is obviously essential that we understand the basic biology underlying such developments at the most fundamental level. Equally important is that we fully appreciate and openly debate the ethical implications of such research.