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Integrative Physiology & Pharmacology Ph.D. Program at Wake Forest University


Wake Forest University Graduate School » Integrative Physiology & Pharmacology Ph.D. Program

Carlos Ferrario, M.D.

Carlos Ferrario, M.D.
Languages Italian , English , Spanish Education & Training BA Mariano Moreno College-Argentina 1956 MD Univ Buenos Aires Faculty of Med-Argentina 1963 Residency Italian Hospital Buenos Aires-Argentina 1965 Internship Italian Hospital Buenos Aires-Argentina 1963 Fellowship Univ Goteborg Med Fac-Sweden 1965 Karolinska Institute-Sweden 1966 Cleveland Clinic Foundation 1969 Memberships Int'L Society of Angiology Int'L Society of Hypertension Int'L Society On Hypertension In Blacks Nat'L Heart Lung & Blood Inst American Heart Association American Physiological Society Association of Black Cardiologists

 

Ferrario CM. ACE2: more of Ang-(1-7) or less Ang II?. Curr Opin Nephrol Hypertens. 2011; 20(1):1-6. Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS ONE. 2011; 6(1):e15759. Varagic J, Ahmad S, Habibi J, Sowers JR, Ferrario CM. Differential regulation of NOS in kidney and heart of SHR fed high salt diet [abstract]. FASEB J. 2011; 25(Meeting Abstracts):643.7. Ferrario CM, Smith RD. Sex differences impact the hemodynamics of untreated essential hypertensive subjects [abstract]. J Clin Hypertens (Greenwich). 2011; 13(Suppl 1):A23. Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Ferrario CM. Olmesartan reduces angiotensin II without affecting ACE activity in kidneys of mRen2.Lewis rats [abstract]. FASEB J. 2011; 25(Meeting Abstracts):1b358. Ferrario CM. ARBITER 6-HALTS. Does it have the power to settle all matters? [editorial]. Ther Adv Cardiovasc Dis. 2010; 4(2):77-81. Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010; 23(6):687-693. DeMarco VG, Johnson MS, Habibi J, Whaley-Connell A, Pulakat L, Winer N, Dellsperger KC, Ferrario C, Sowers JR. Effects of telmisartan on cardiovascular and metabolic function in the TG(mRen2)27 rat, a model of hypertension and insulin resistance [abstract]. Hypertension. 2010; 56(5):e77. Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. Am J Physiol Heart Circ Physiol. 2010; 299(3):H763-H771. Ferrario C. Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil. Russ J Cardiol. 2010; (6):94-106. Wysocki J, Ye M, Rodriguez E, Gonzalez-Pacheco FR, Barrios C, Evora K, Schuster M, Brosnihan KB, Ferrario CM, et al. Targeting the degradation of angiotensin II with recombinant angiotensin-convertng enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 2010; 55(1):90-98. Joyner-Grantham J, Simmons DR, Moore MA, Ferrario CM. The impact of changing ICD code on hypertension-related mortality in the Southeastern United States from 1994-2005. J Clin Hypertens (Greenwich). 2010; 12(3):213-222. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010; 4(1):17-25. Ferrario CM. Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control. Life Sci. 2010; 86(9-10):289-299. Hayden MR, Habibi J, Whaley-Connell A, Sowers D, Johnson M, Tilmon R, Jain D, Ferrario C, Sowers JR. Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats. Am J Nephrol. 2010; 31(3):262-272. Ahmad S, Varagic J, Westwood B, Chappell MC, Strawn WB, Simmons T, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue [abstract]. FASEB J. 2010; 24(1 Meeting Abstracts):605.4. Ferrario CM, Flack JM, Strobeck JE, Smits G, Peters C. Individualizing hypertension treatment with impedance cardiography: a meta-analysis of published trials. Ther Adv Cardiovasc Dis. 2010; 4(1):5-16. Ferrario CM, Smith RD. Role of olmesartan in combination therapy in blood pressure control and vascular function. Vasc Health Risk Manag. 2010; 6():701-709. Ferrario CM, Ahmad S, Joyner J, Varagic J. Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). Adv Pharmacol. 2010; 59():197-233. Ferrario CM. Harmonic complexity within the renin angiotensin system: role of the Ang-(1-7)/ACE2/mas receptor axis [abstract]. Endocr J. 2010; 57(Suppl 2):S267. DeMarco VG, Whaley-Connell A, Habibi J, Ma LX, Pulakat L, Ferrario C, Sowers J. Mineralocorticoid receptor blockade attenuates myocardial oxidative stress and improves diastolic function in the (TGR)Ren2 rat [abstract]. Hypertension. 2010; 56(5):e78. Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. Protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling. Russ J Cardiol. 2010; 5():83-90. Ferrario CM. New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension. 2010; 55(2 Pt 2):445-452. Whaley-Connell A, Nistala R, Habibi J, Hayden MR, Schneider RI, Johnson MS, Rehmer N, Ferrario CM, Sowers JR. Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat. Am J Physiol Renal Physiol. 2010; 298(3):F655-61. Smith RD, Yokoyama H, Averill DB, Schiffrin EL, Ferrario CM. Reversal of vascular hypertrophy in hypertensive patients through blockade of angiotensin II receptors. Cardiovasc Ther Prev. 2010; 9(6):17-24. Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM. Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Am J Nephrol. 2010; 32(6):557-566. Ferrario CM, Varagic J. The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function. Am J Physiol Renal Physiol. 2010; 298(6):F1297-305. Varagic J, Ahmad S, Brosnihan KB, Habibi J, Sowers JR, Ferrario CM. The effects of nebivolol on salt-induced renal injury [abstract]. Hypertension. 2010; 56(5):e155. Wei Y, Whaley-Connell AT, Habibi J, Rehmer J, Rehmer N, Patel K, Hayden M, DeMarco V, Ferrario CM, Ibdah JA, et al. Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation. Hypertension. 2009; 53(2):158-165. Ferrario CM. Editorial: journal accomplishments in just one short year [editorial]. Ther Adv Cardiovasc Dis. 2009; 3(1):5. Ferrario CM. Harmonic complexity within the renin angiotensin system: role of the Ang-(1-7)/Ace2/mas receptor axis [abstract]. Hypertension. 2009; 53(6):1106. Whaley-Connell A, Habibi J, Wei Y, Gutweiler Z, Jellison J, Wiedmeyer CE, Ferrario CM, Sowers JR. Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat. Am J Physiol Renal Physiol. 2009; 296(5):F1013-1022. Schindler C, Ferrario CM, Brosnihan BK [sic] [Brosnihan KB], Idelevich E, Siegert J, Kirch W. Atorvastatin mediates pleiotropic effects in hypercholesterolemic patients via the Renin-Angiotensin-System (RAS) by increasing angiotensin-(1-7) [abstract]. Naunyn Schmiedebergs Arch Pharmacol. 2009; 379(Suppl 1):92. DeMarco VG, Habibi J, Whaley-Connell AT, Schneider RI, Sowers JR, Andresen BT, Gutweiler AA, Ma L, Johnson MS, Ferrario CM, et al. Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat. Am J Physiol Heart Circ Physiol. 2009; 297(3):H1128-1139. Ferrario CM. Memorial: Juan Carlos Romero MD. Ther Adv Cardiovasc Dis. 2009; 3(2):101. Lastra G, Habibi J, Whaley-Connell AT, Manrique C, Hayden MR, Rehmer J, Patel K, Ferrario C, Sowers JR. Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression. Endocrinology. 2009; 150(6):2561-2568. Alfany-Fernandez I, Casillas-Ramirez A, Bintanel-Morcillo M, Brosnihan KB, Ferrario CM, Rimola A, Arroyo V, Rodes J, Rosello-Catafau J, Peralta C. Therapeutic targets in liver transplantation: angiotensin II in non-steatotic grafts and angiotensin-(1-7) in steatotic grafts [abstract]. J Hepatol. 2009; 50(Suppl 1):S63. Whaley-Connell A, Habibi J, Johnson M, Tilmon R, Rehmer N, Rehmer J, Wiedmeyer C, Ferrario CM, Sowers JR. Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat. Am J Nephrol. 2009; 30(4):354-360. Nistala R, Habibi J, Rehmer N, Rehmer J, Hayden MR, Ferrario CM, Whaley-Connell AT, Sowers JR. Direct renin inhibition abrogates glomerular filtration barrier injury in the transgenic Ren2 rat [abstract]. Hypertension. 2009; 54(4):e83. Varagic J, Ahmad S, Brosnihan KB, Ferrario CM. Spironolactone and angiotensin-(1-7) in salt-induced cardiac injury [abstract]. Hypertension. 2009; 54(4):e26. Joyner-Grantham J, Mount DL, McCorkle OD, Simmons DR, Ferrario CM, Cline DM. Self-reported influences of hopelessness, health literacy, lifestyle action, and patient inertia on blood pressure control in a hypertensive emergency department population. Am J Med Sci. 2009; 338(5):368-372. Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell A, Sowers JR. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol Heart Circ Physiol. 2009; 296(4):H1184-1192. Wei Y, Clark SE, Thyfault JP, Uptergrove GM, Li W, Whaley-Connell AT, Ferrario CM, Sowers JR, Ibdah JA. Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats. Am J Pathol. 2009; 174(4):1329-1337. Schindler C, Ferrario CM, Brosnihan KB, Idelevich E, Siegert J, Bocking W, Kirch W. Atorvastatin increases plasma levels of the pleiotropic RAS-peptide angiotensin-(1-7) in hypercholesterolemic patients [abstract]. Basic Clin Pharmacol Toxicol. 2009; 104(6):517. Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2009; 297(1):R111-115. Levy PJ, Strawn WB, Brosnihan KB, Moore LC, Holbrook JB, Hansen KJ, Ferrario CM. Angiotensin II receptor blockade increases endothelial repair potential in younger adults with severe peripheral arterial disease (PAD) [abstract]. J Thromb Haemost. 2009; 7(Suppl 2):918. Ferrario C. Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil. Vasc Health Risk Manag. 2009; 5(1):301-314. Trask AJ, Ferrario CM. The renin-angiotensin system and the heart. In: Singh AK, Williams GH, eds. Textbook of nephro-endocrinology. Boston (MA): Academic Press Inc.; 2009: 181-188. Ahmad S, Varagic J, Westwood B, Chappell MC, Ferrario CM. Uptake of novel peptide angiotensin-(1-12) by cardiac myocytes [abstract]. Hypertension. 2009; 54(4):e111. Alfany-Frenandez I, Casillas-Ramirez A, Bintanel-Morcillo M, Brosnihan KB, Ferrario CM, Serafin A, Rimola A, Rodes J, Rosello-Catafau J, Peralta C. Therapeutic targets in liver transplantation: angiotensin II in nonsteatotic grafts and angiotensin-(1-7) in steatotic grafts. Am J Transplant. 2009; 9(3):439-451. Ferrario CM, Moore MA, Copeland L. The economic challenges in healthcare: the effect on quality. Am J Med Sci. 2009; 337(6):391-393. Ye MH, Wysocki J, Rodriguez E, Barrios C, Schuster M, Loibner H, Penninger JM, Ferrario CM, Batlle D. The in vivo effect of recombinant ACE2 on angiotensin II and angiotensin-(1-7) levels [abstract]. Hypertension. 2009; 54(4):e112. Schindler C, Ferrario CM, Jatzke C, Ahner K, Brosnihan KB, Bramlage P, Maywald U, Oertel R, Boecking W, Kirch W. Characterization of vascular reactivity in dorsal hand veins after oral rosiglitazone treatment in healthy subjects. Int J Clin Pharmacol Ther. 2008; 46(1):30-39. Diz DI, Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Averill DB. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008; 51(6):542-548. Garcia-Espinosa MA, Shaltout HA, Chappell MC, Gallagher PE, Ferrario CM, Ganten D, Reudelhuber TL, Diz DI. Angiotensin-(1-7) replacement gene transfer in the cisterna magna lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats [abstract]. Hypertension. 2008; 52(4):e36. Logan EM, Diz DI, Ferrario CM, Ganten D, Aileru AA. Differences in ganglionic transmission between (mRen)27 and mRen2.Lewis models of hypertension [abstract]. Hypertension. 2008; 52(4):e65. Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008; 2(2):106-115. Trask AJ, Jessup JA, Tallant EA, Chappell MC, Ferrario CM. Renin-independent processing of angiotensin-(1-12) in the rat heart and isolated myocytes [abstract]. Hypertension. 2008; 52(4):e45-e46. Trask AJ, Groban L, Varagic J, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 aggravates cardiac hypertrophy in Ren-2 hypertensive rats [abstract]. Hypertension. 2008; 52(4):e126. Ferrario CM. Questions to ponder [editorial]. Ther Adv Cardiovasc Dis. 2008; 2(6):417-418. Joyner J, Neves LAA, Stovall K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats. Am J Physiol Regul Integr Comp Physiol. 2008; 294(3):R1073-1080. Brosnihan KB, Li P, Figueroa JP, Ganten D, Ferrario CM. Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats. Am J Physiol Heart Circ Physiol. 2008; 294(5):H1995-2001. Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 2008; 93(5):613-621. Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. New angiotensins. J Mol Med. 2008; 86(6):663-671. Gallagher PE, Ferrario CM, Tallant EA. MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. Am J Physiol Cell Physiol. 2008; 295(5):C1169-1174. Arnold AC, Shaltout HA, Gallagher PE, Ganten D, Ferrario CM, Diz DI. Leptin impairs baroreflex sensitivity at the solitary tract nucleus: evidence for upregulation of leptin actions in animals with low brain angiotensinogen [abstract]. Hypertension. 2008; 52(4):e50. Brosnihan KB, Anton L, Neves L, Moorefield C, Gruver C, Ferrario C, Merrill D. Ang II and Ang-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi [abstract]. Hypertens Pregnancy. 2008; 27(4):510. Ferrario CM, Chappell MC. Angiotensin formation and degradation. In: Izzo JL, Sica DA, Black HR, eds. Hypertension primer: the essentials of high blood pressure: basic science, population science, and clinical management. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2008: 52-54. Anton L, Merrill DC, Neves LAA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preelampsia. Hypertension. 2008; 51(4):1066-1072. Brosnihan KB, Pazzine M, Neves LA, Ferrario CM. Pregnancy stimulates a differential contribution of AT1 and AT1-7 receptors to renal and uterine blood flow [abstract]. Hypertension. 2008; 52(4):e92. Logan EM, Diz DI, Ferrario CM, Ganten D, Averill DB. Inhibition of the PI3 kinase pathway in the nTS of hypertensive rats improves baroreceptor reflex sensitivity [abstract]. Hypertension. 2008; 52(4):e80. Wei YZ, Whaley-Connell AT, Rehmer JM, Rehmer NT, Ferrario CM, Ibdah JA, Sowers JR. Mineralocorticoid receptor blockage attenuates vascular apoptosis, inflammation, and oxidative stress in the renin transgenic Ren2 rat [abstract]. Hypertension. 2008; 52(4):e77. Wei Y, Clark SE, Morris EM, Thyfault JP, Uptergrove GME, Whaley-Connell AT, Ferrario CM, Sowers JR, Ibdah JA. Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. J Hepatol. 2008; 49(3):417-428. Wei Y, Sowers JR, Clark SE, Li W, Ferrario CM, Stump CS. Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappa B activation via NADPH oxidase. Am J Physiol Endocrinol Metab. 2008; 294(2):E345-E351. Ferrario CM. On the selective inhibitors of cyclooxygenase-2: do we have a last word? [editorial]. Ther Adv Cardiovasc Dis. 2008; 2(2):75-78. Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low-dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008; 2(2):106-115. Trask AJ, Jessup JA, Chappell MC, Ferrario CM. Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol Heart Circ Physiol. 2008; 294(5):H2242-2247. Brosnihan KB, Anton L, Neves LAA, Moorefield C, Gruver C, Ferrario CM, Merrill DC. Ang II and Ang-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi [abstract]. J Hypertens. 2008; 26(Suppl 1):S16. Jessup JA, Trask AJ, Chappell MC, Nagata S, Kato J, Kitamura K, Ferrario CM. Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats. Am J Physiol Heart Circ Physiol. 2008; 294(6):H2614-2618. Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Tallant EA, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008; 93(5):694-700. Igase M, Kohara K, Nagai T, Miki T, Ferrario CM. Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade. Hypertens Res. 2008; 31(3):553-559. Lastra G, Whaley-Connell A, Manrique C, Habibi J, Gutweiler AA, Appesh L, Hayden MR, Wei Y, Ferrario C, Sowers JR. Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat. Am J Physiol Endocrinol Metab. 2008; 295(1):E110-E116. Anton L, Merrill DC, Diz D, Neves LA, Gallagher PE, Stovall K, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Elevation of maternal uterine placental bed angiotensin II levels is associated with increased renin and ACE mRNA in preeclampsia [abstract]. Hypertension. 2008; 52(4):e49. Ferrario CM, Varagic J, Chappell MC, Trask AJ, Nagata S, Kato J. Bilateral nephrectomy augments the cardiac content of angiotensin-(1-12) and angiotensin I in Wistar Kyoto rats [abstract]. Hypertension. 2008; 52(4):e126. Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) contributes to renin-independent angiotensin II activity in brain [abstract]. Hypertension. 2008; 52(4):e81. Neves LAA, Stovall K, Joyner J, Valdes G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Am J Physiol Regul Integr Comp Physiol. 2008; 294(1):R151-R161. Ferrario CM. Of gender, statins, and coronary artery interventions [editorial]. Ther Adv Cardiovasc Dis. 2008; 2(2):73-74. Pendergrass KD, Pirro NT, Westwood BM, Ferrario CM, Brosnihan KB, Chappell MC. Sex differences in circulating and renal angiotensins of hypertensive mRen(2).Lewis but not normotensive Lewis rats. Am J Physiol Heart Circ Physiol. 2008; 295(1):H10-H20. Anton L, Merrill D, Diz D, Neves L, Gallagher P, Stovall K, Moorefield C, Gruver C, Ferrario C, Brosnihan KB. Does the activated RAS with suppression of all Ang receptors in the preeclamptic maternal uterus play an endocrine role on the placenta? [abstract]. Hypertens Pregnancy. 2008; 27(4):508. Strawn WB, Ferrario CM. Angiotensin II AT1 receptor blockade normalizes CD11b+ monocyte production in bone marrow of hypercholesterolemic monkeys. Atherosclerosis. 2008; 196(2):624-632. Whaley-Connell A, Habibi J, Nistala R, Cooper SA, Karuparthi PR, Hayden MR, Rehmer N, DeMarco VG, Andresen BT, Ferrario C, et al. Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment. Hypertension. 2008; 51(2 Pt 2):474-480. Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen. Hypertension. 2008; 51(5):1326-1331. Tallant EA, Gallagher PE, Ferrario CM, inventors; Wake Forest University Health Sciences, assignee. Angiotensin (1-7) and angiotensin (1-7) agonists for inhibition of cancer cell growth. United States patent US 7,375,073. 2008 May 20. 2008; ():. Whaley-Connell A, Habibi J, Cooper SA, DeMarco VG, Hayden MR, Stump CS, Link D, Ferrario CM, Sowers JR. Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat. Am J Physiol Endocrinol Metab. 2008; 295(1):E103-E109. Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts. Am J Physiol Heart Circ Physiol. 2008; 295(6):H2373-79. Joyner J, Neves LAA, Ferrario CM, Brosnihan KB. Administration of D-alanine-[Ang-(1-7)] (A-779) prior to pregnancy in Sprague Dawley rats produces antidiuresis in late gestation. J Am Soc Hypertens. 2008; 2(6):425-430. Habibi J, Whaley-Connell A, Hayden MR, DeMarco VG, Schneider R, Sowers SD, Karuparthi P, Ferrario CM, Sowers JR. Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat. Endocrinology. 2008; 149(11):5643-5653. Habibi J, Whaley-Connell A, Qazi MA, Hayden MR, Cooper SA, Tramontano A, Thyfault J, Stump C, Ferrario C, Muniyappa R, et al. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats. Endocrinology. 2007; 148(5):2181-2188. Morris RT, Fine DM, Lees SJ, Booth FW, Ferrario CM, Sowers JR, Stump CS. Exercise training maintains cardiac output and stroke volume in hypertensive TG (mREN-2)27 rats with impaired diastolic function [abstract]. FASEB J. 2007; 21(6):A930. Wei Y, Whaley-Connell AT, Chen K, Habibi J, Uptergrove GM, Clark SE, Stump CS, Ferrario CM, Sowers JR. NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat. Hypertension. 2007; 50(2):384-391. Stas S, Whaley-Connell A, Habibi J, Appesh L, Hayden MR, Karuparthi PR, Qazi M, Morris EM, Cooper SA, Ferrario C, et al. Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling. Endocrinology. 2007; 148(8):3773-3780. Jessup JA, Ferrario CM, Chappell MC, Nagata S, Kato J, Kitamura K. Localization of the novel angiotensin peptide, proangiotensin-12, in the heart and kidney of hypertensive and normotensive rats [abstract]. Hypertension. 2007; 50(4):e101. Logan EM, Ferrario CM, Diz DI, Averill DB. The PI3 kinase signal transduction pathway in nucleus tractus solitarii participates in maintenance of resting arterial [abstract]. Hypertension. 2007; 50(4):e116. Varagic J, Brosnihan KB, Groban L, Gallagher PE, Ferrario CM. Decreased expression of cardiac ACE2 is associated with salt-induced cardiac remodeling and dysfunction [abstract]. Hypertension. 2007; 50(4):e150. Whaley-Connell AT, Nistala R, Cooper SA, Morris EM, Habibi J, Stump CS, Ferrario C, Sowers JR. Rosuvastatin abrogation of angiotensin-II stimulation of NAD(P)H oxidase activity in vivo and isoform expression in podocytes in vitro [abstract]. Hypertension. 2007; 50(4):e101-e102. Menon J, Soto-Pantoja DR, Callahan MF, Cline JM, Ferrario CM, Tallant EA, Gallagher PE. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Res. 2007; 67(6):2809-2815. Brosnihan KB, Neves LAA, Stovall K, Ferrario CM. Decidualization of pseduopregnant uterus is associated with marked reduction in Ang II and Ang-(1-7) content [abstract]. FASEB J. 2007; 21(6 Pt II):A1252. Wei Y, Sowers JR, Clark SE, Ferrario CM, Stump CS. Angiotensin II-induced insulin resistance in skeletal muscle by activation of nuclear factor kB via NADPH oxidase [abstract]. FASEB J. 2007; 21(5):A663. Brosnihan KB, Stovell K, Gallagher PE, Ferrario CM, Neves LA. Intrauterine Ang-(1-7) infusion attenuates PGE2 and PGF1 alpha but not TXB2 in decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2007; 50(4):e102. Trask AJ, Jessup J, Ferrario CM. Angiotensin-(1-12) is a precursor for the processing of cardiac tissue angiotensin peptides [abstract]. Hypertension. 2007; 50(4):e154. Cline D, Ayala C, Caskie D, Ferrario C. Patient specific feedback increases referral of hypertensive emergency department patients: a randomized controlled trial [abstract]. Acad Emerg Med. 2007; 14(5 Suppl 1):S117. Joyner J, Neves LA, Stovall K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) increases water intake and produces diuresis in association with down-regulation of aquaporin-1 during pregnancy in rats [abstract]. FASEB J. 2007; 21(6 Pt II):A1245. Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Baroreceptor reflex regulation in anesthetized older transgenic rats with low brain angiotensinogen: role of endogenous angiotensin II and angiotensin-(1-7) [abstract]. FASEB J. 2007; 21(6 Pt II):A889. Smith R, Ferrario C, Walker F. Number of antihypertensive agents required to achieve goal blood pressure with an Olmesartan Medoxomil vs Atenolol based regimen [abstract]. J Hypertens. 2007; 25(Suppl 2):S240-S241. Whaley-Connell A, Govindarajan G, Habibi J, Hayden MR, Cooper SA, Wei Y, Ma L, Qazi M, Link D, Ferrario C, et al. Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat. Am J Physiol Endocrinol Metab. 2007; 293(1):E355-363. Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol. 2007; 292(3):H1412-1419. Schindler C, Brosnihan KB, Ferrario CM, Bramlage P, Maywald U, Koch R, Oertel R, Kirch W. Comparison of inhibitory effects of irbesartan and atorvastatin treatment on the renin angiotensin system (RAS) in veins: a randomized double-blind crossover trial in healthy subjects. J Clin Pharmacol. 2007; 47(1):112-120. Hayden MR, Chowdhury NA, Cooper SA, Whaley-Connell A, Habibi J, Witte L, Wiedmeyer C, Manrique CM, Lastra G, Ferrario C, et al. Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2007; 292(2):F861-F867. Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM. Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats. Am J Physiol Heart Circ Physiol. 2007; 292(6):H3019-3024. Pignone A, Del Rosso A, Brosnihan KB, Perfetto F, Livi R, Fiori G, Guiducci S, Cinelli M, Rogai V, Ferrario CM, et al. Reduced circulating levels of angiotensin-(1-7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Ann Rheum Dis. 2007; 66(10):1305-1310. De Mello WC, Ferrario CM, Jessup JA. Beneficial versus harmful effects of angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst. 2007; 8(2):74-80. Wei YZ, Clark S, Morris EM, Thyfault J, Uptergrove G, Whaley-Connel A, Ferrario CM, Sowers JR, Ibdah JA. Angiotensin II causes progressive nonalcoholic fatty liver disease mediated by oxidative stress in the Ren-2 rat model [abstract]. Hepatology. 2007; 46(4 Suppl):751A. Ferrario CM, Cooper M, Heagerty A, Schindler C, Suzuki H. Editorial. Ther Adv Cardiovasc Dis. 2007; 1(1):5-6. Trask AJ, Ferrario CM. Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments. Cardiovasc Drug Rev. 2007; 25(2):162-174. Ferrario CM, Lara PA, Coca A, Martell N, Redon J, Rodicio JL, Ruilope LM. Memorial to Manuel Luque Otero, MD: May 24, 1943 to June 15, 2007 [in memoriam]. Hypertension. 2007; 50(4):595. Gironacci MM, Brosnihan KB, Ferrario CM, Gorzalczany S, Verrilli MAL, Pascual M, Taira C, Pena C. Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertension. Peptides. 2007; 28(8):1580-1585. Ferrario CM, Basile J, Bestermann W, Frohlich E, Houston M, Lackland DT, Smith RD, Wise DL. The role of noninvasive hemodynamic monitoring in the evaluation and treatment of hypertension. Ther Adv Cardiovasc Dis. 2007; 1(2):113-118. Diz DI, Kasper SO, Sakima A, Ferrario CM. Aging and the brain renin-angiotensin system: insights from studies in transgenic rats. Cleve Clin J Med. 2007; 74(Suppl 1):S95-S98. Joyner J, Neves LAA, Granger JP, Alexander BT, Merrill DC, Chappell MC, Ferrario CM, Davis WP, Brosnihan KB. Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2007; 293(1):R169-R177. Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Ang II and Ang-(1-7) in the solitary tract nucleus participate in the anesthesia-induced elevation of mean arterial pressure in older rats with low glial angiotensinogen [abstract]. Hypertension. 2007; 50(4):e116. Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Diz DI, Gallagher PE, Neves L, Tallant EA. Regulation of cardiovascular control mechanisms by angiotensin (1-7) and angiotensin-converting enzyme 2. In: Carey RM, ed. Hypertension and hormone mechanisms. Totowa (NJ): Humana Press; 2007: 43-59. Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007; 292(1):F82-F91. Chappell MC, Westwood BM, Pendergrass KD, Jessup J, Ferrario CM. Distinct processing pathways for the novel peptide angiotensin-(1-12) in the serum and kidney of the hypertensive mRen2.Lewis rat [abstract]. Hypertension. 2007; 50(4):e139. Trask AJ, Chappell MC, Ferrario CM. Major role for angiotensin-converting enzyme 2 in cardiac angiotensin-(1-7) production in the congenic hypertensive mRen2.Lewis rat [abstract]. Hypertension. 2007; 50(4):e140. Schindler C, Bramlage P, Kirch W, Ferrario CM. Role of the vasodilator peptide angiotensin-(1-7) in cardiovascular drug therapy. Vasc Health Risk Manag. 2007; 3(1):125-137. Anton L, Merrill DC, Diz DI, Neves LA, Stovall K, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated by the AT1 receptor [abstract]. Hypertension. 2007; 50(4):e79. Joyner J, Neves LA, Stovall K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) increases urine volume excretion without changing plasma volume or blood pressure during pregnancy [abstract]. Hypertension. 2007; 50(4):e78. Whaley-Connell AT, Cooper SA, Habibi J, Hayden MR, Stump CS, Link CD, Ferrario C, Sowers JR. The effect of renin inhibition on cardiac oxidative stress and remodeling in the Ren2 transgenic rat [abstract]. Hypertension. 2007; 50(4):e102. Groban L, Ferrario CM, Ganten D, Diz DI. Transgenic rats with low brain renin-angiotensin system activity due to glial deficiency are protected against heart failure late in life [abstract]. J Card Fail. 2007; 13(6 Suppl 2):S83. Ferrario CM, Strawn WB. Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am J Cardiol. 2006; 98(1):121-128. Joyner J, Neves LAA, Gallagher PE, Chappell MC, Ferrario CM, Brosnihan KB. Kidney ACE2 mRNA and activity in virgin and normal pregnant Sprague Dawley rats [abstract]. J N C Acad Sci. 2006; 122(2):80. Ferrario CM, Smith RD. Cost-effectiveness of impedance cardiography testing in uncontrolled hypertension. Am Heart Hosp J. 2006; 4(4):279-289. Igase M, Kohara K, Nagal T, Ferrario C, Miki T. Role of ACE2 in the reduction of neointima by AT1 receptor blockade [abstract]. J Hypertens. 2006; 24(Suppl 6):86. Chappel [sic] MC [Chappell MC], Ferrario CM. ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin-(1-7) [commentary]. Kidney Int. 2006; 70(1):8-10. Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study) : rationale and baseline characteristics. Am J Cardiovasc Drugs. 2006; 6(5):335-342. Anton L, Merrill DC, Neves LA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased expression of AT1 receptor and angiotensinogen mRNA and Ang II in human placental chorionic villi of preeclamptic pregnant subjects [abstract]. Hypertension. 2006; 48(4):e95. Ferrario CM. A critical contribution of angiotensin II in the pathogenesis of vascular disease and stroke [abstract]. J Hypertens. 2006; 24(Suppl 6):37. Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Reudlehuber TL, Diz DI. Intracisternal injection of angiotensin-(1-7)-producing fusion protein plasmid lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. Hypertension. 2006; 48(4):e87. Levy PJ, Jackson SA, McCoy TP, Ferrario CM. Clinical characteristics of patients with premature lower extremity atherosclerosis associated with familial early cardiovascular disease and/or cancer. Int Angiol. 2006; 25(3):304-309. Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Am J Physiol Heart Circ Physiol. 2006; 291(5):H2166-2172. Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Ferrario C, et al. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006; 291(6):F1308-1314. Smith RD, Yokoyama H, Levy PJ, Ferrario CM. Non-invasive hemodynamic data reflect treatment effects on vascular remodeling [abstract]. J Hypertens. 2006; 24(Suppl 4):S351. Smith RD, Yokoyama H, Brosnihan KB, Ferrario CM. Inflammatory markers (IM) in uncomplicated hypertension [abstract]. J Hypertens. 2006; 24(Suppl 6):111. Smith RD, Averill DB, Brosnihan KB, Ferrario CM. Effects of antihypertensive therapy on insulin sensitivity and leptin values [abstract]. J Hypertens. 2006; 24(Suppl 6):112-113. Tallant EA, Ferrario CM, Gallagher PE. Cardioprotective role for angiotensin-(1-7) and angiotensin converting enzyme 2 in the heart. Future Cardiol. 2006; 2(3):335-342. Neves LAA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006; 27(11):2912-2918. Ferrario CM, Smith RD. Response to reduction of blood pressure levels study group [reply to letter]. Hypertension. 2006; 48(5):e105. Kasper SO, Sakima A, Ferrario CM, Ganten D, Diz DI. Altered stress responses in rats with low glial angiotensinogen [abstract]. Am J Med Sci. 2006; 331(2):63. Neves LA, Stovall K, Gallagher PE, Valdes G, Ferrario CM, Merrill DC, Brosnihan KB. Ang-(1-7) concentration and ACE2 mRNA levels are downregulated during the process of implantation and decidualization in Sprague-Dawley rats [abstract]. Hypertens Pregnancy. 2006; 25(Suppl 1):20. Reyes-Engel A, Morcillo L, Aranda FJ, Ruiz M, Gaitan MJ, Mayor-Olea A, Aranda P, Ferrario CM. Influence of gender and genetic variability on plasma angiotensin peptides. J Renin Angiotensin Aldosterone Syst. 2006; 7(2):92-97. Kasper SO, Ferrario CM, Ganten D, Diz DI. Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging. Endocrine. 2006; 30(2):167-174. Strawn WB, Ferrario CM. Pioglitazone normalizes function of endothelial progenitor cells from hypercholesterolemic monkeys [abstract]. Circ Res. 2006; 99(11):1280. Jessup JA, Gallagher PE, Chappell MC, Ferrario CM. Impaired counter-regulatory response of angiotensin converting enzyme 2 (ACE2) and angiotensin-(1-7) [Ang-(1-7)] in the heart of a new congenic model of hypertension derived from [mRen2]27 transgenic rats [abstract]. Hypertension. 2006; 48(4):e74. Joyner J, Neves L, Gallagher P, Merrill D, Ferrario C, Brosnihan KB. Counter-regulation of ACE and ACE2 gene expression in the kidney of normal pregnant rats [abstract]. Hypertension. 2006; 48(4):e95. Sakima A, Averill DB, Kasper SO, Tommasi E, Gilliam-Davis S, Jackson L, Ganten D, Ferrario CM, Diz D. Cardiovascular and autonomic control in transgenic rats with low glial-derived angiotensinogen [abstract]. J Hypertens. 2006; 24(Suppl 6):157. Ferrario CM, Smith RD. Cost-effectiveness of impedance cardiography testing in uncontrolled hypertension [abstract]. Circulation. 2006; 114(18 Suppl):827. Fitch MT, Benfield J, Hargraves J, Ferrario CM, Ayala C, Lekiachvili A, Neiberg R, Cline DM. Hospital admission rate for chest pain: are racial differences due to bias or disease characteristics? [abstract]. Ann Emerg Med. 2006; 48(4 Suppl):S44. Ferrario CM. Preferential effects of angiotensin receptor blocker (ARB) therapy on vascular structure: results of the Vascular Improvement with Olmesartan Medoxomil Study (VIOS) [abstract]. J Hypertens. 2006; 24(Suppl 6):414. Wei Y, Stump CS, Resch ZT, Uptergrove GM, Cooper SA, Clark SE, Ferrario CM, Sowers JR. NAD(P)H oxidase activation induced reactive oxygen species accumulation and enhanced vasoconstriction in Ren-2 rat aortas [abstract]. Hypertension. 2006; 48(4):e54. Basile J, Houston M, Ferrario C. Incremental risk-factor reduction improves overall cardiovascular benefit: is it time to abandon the silos? [editorial]. J Clin Hypertens. 2006; 8(10):686-688. Garcia-Espinosa MA, Vinsant S, Gallagher PE, Ferrario CM, Ganten D, Chappell MC, Diz DI. Regulation of brain neprilysin and ACE2 in transgenic rats during aging [abstract]. Am J Med Sci. 2006; 331(2):61. Diz DI, Tommasi EN, Ferrario CM, Tallant EA, Gallagher PE. ACE2 inhibition in the nucleus of the solitary tract reduces baroreceptor reflex sensitivity [abstract]. Hypertension. 2006; 48(4):e87. Gallagher PE, Ferrario CM, Tallant EA. Molecular mechanisms for the regulation of angiotensin converting enzyme 2 by angiotensin peptides in vascular smooth muscle cells [abstract]. Hypertension. 2006; 48(4):e72. McCollum LT, Gallagher PE, Ferrario CM, Tallant EA. Angiotensin-(1-7) reduces COX-2 in cardiac fibroblasts [abstract]. Hypertension. 2006; 48(4):e79. Trask AJ, Averill DB, Chappell MC, Ferrario CM. Predominance of angiotensin converting enzyme 2 to cardiac angiotensin-(1-7) production in [mRen2]27 transgenic hypertensive rats [abstract]. Hypertension. 2006; 48(4):e72. Basile J, Houston M, Ferrario CM. Treating the cardiometabolic syndrome: an opportunity to provide comprehensive cardiovascular risk reduction. J Cardiometab Syndr. 2006; 1(5):358-361. Gallagher PE, Tallant EA, Ferrario CM. Angiotensin converting enzyme 2: a potential target for cardiovascular therapy. In: Re RN, DiPette DJ, Schiffrin EL, Sowers JR, eds. Molecular mechanisms in hypertension. New York: Taylor & Francis; 2006: 51-59.